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KMID : 0903520050480030246
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2005 Volume.48 No. 3 p.246 ~ p.251
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Efficacy Study of Activation on Macrophage in Germanium-fortified Yeast
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Lee Sung-Hee
Rho Sook-Nyung
Sohn Tsang-Uk
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Abstract
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The aim of this study was to evaluate an efficacy about activation on macrophage, using model that measured cell viability, nitric oxide (NO), iNOS (inducible nitric oxide synthase) expression and tumor necrosis factor-α (TNF-α) on Raw 264.7 cells following treatment of Germanium-fortified Yeast in 0, 5, 10, 25, 50, 100, 200 μg/ml and the same concentration of dried yeast without germanium. Cell viability (%) and NO produced in activated-macrophage were dose-dependant, a significant increase of the cell viability (132.5%) and NO in 10 μg/ml (p < 0.05). Increase in iNOS level was in 10 μg/ml. TNF-α was produced dose-dependant, e.g. in activated-macrophage with a significant increase of the TNF-α in 5 and 10 μg/ml (p < 0.05). Therefore, Germanium-fortified Yeast had an efficacy of NO mediated iNOS and TNF-α production by activated macrophage. This result showed that Germanium-fortified Yeast induced activation of cellular immunity, returned to normalcy on injured immune system and procured anticancer system by activation of macrophage, which was important in immune and anticancer function.
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KEYWORD
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Germanium-fortified Yeast, macrophage, immune system
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